Inhibitors and UnCouplers of Oxidative Phosphorylation

Inhibitors and UnCouplers of Oxidative Phosphorylation

Ability to harness energy from external sources and utilize it for biological work is characteristic of all living organisms. Phototrophs harvest the energy of light (Plants). Chemotrophs harvest energy from oxidation of fuel molecules.  The oxidation of foodstuffs occurs in three stages. Oxidative Stages of Food Stuff: 1. Primary Metabolism: ...

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Oxidative Phosphorylation

Oxidative Phosphorylation: Fate of Electrons in Mitochondria

The coupling of oxidation with phosphorylation is termed “Oxidative phosphorylation”, which takes place during the electron transport in the inner membrane. DEFINITION: What is the definition of Oxidative Phosphorylation. The Endergonic synthesis of ATP from ADP and pi in mitochondria is called “Oxidative phosporylation”, which is catalyzed by the enzyme ...

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Electron Transport Chain Mechanism and inhibitors

Electron Transport Chain Mechanism in Mitochondria

The electron carriers of the respiratory chain are organized into the membrane embedded supra molecular complexes that can be physically separated. Gentle treatment of the inner mitochondrial membrane with detergents allows the resolution of four unique electron – carrier complexes, each capable of catalyzing electron transfer through a portion of ...

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Why Gluconeogenesis is Important? (Simple Notes)

Gluconeogenesis: Why this is very Important? (Simple Notes)

Gluconeogenesis is the process of synthesizing glucose from non-carbohydrate sources. Gluconeogenesis occurs mainly in liver. Gluconeogenesis occurs to a more limited extent in the kidney and small intestine under some conditions. The starting point of gluconeogenesis is pyruvic acid, although oxaloacetic acid and dihydroxyacetone phosphate also provide entry points. Lactic ...

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Fatty Acid Synthesis Activation, Steps and Control

Fatty Acid Synthesis: Activation, Steps and Control

Fatty acid synthesis occurs similarly to Beta-oxidation – acetyl groups are added to a growing chain, but the mechanism of the pathway is distinctly different from being simply the reverse of Beta-oxidation. Fatty acid synthesis occurs in the cytosol (not mitochondria). It uses a moiety called Acyl-carrier protein (ACP) instead ...

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Fatty acids : Building Blocks of Fats and Oils

Fatty acids : Building Blocks of Fats and Oils

Fats are esters of high molecular weight containing fatty acids and glycerol. Glycerol is a trihydric alcohol and therefore one two or all the three hydroxyl groups (OH) can react with fatty acids forming mono, di or triglycerides respectively. Alcohols commonly include Glycerol, Cholesterol and higher alcohols such as cetyl ...

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